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Sarah-Maria Fendt

Sarah-Maria Fendt

Postdoctoral Fellow

fendts@mit.edu

Research:

During my PhD I studied the transcriptional regulation of metabolism in yeast. My postdoctoral work is focused on the elucidation of metabolic alterations in cancer cells. As readout I measure cell physiology, carbon source distribution, and regulator activity in cells harboring various gene mutations and deletions.

Education:

2009 Ph.D. ETH Zurich, Switzerland

2005 M.Sc. TU Munich, Germany

2003 B.Sc. TU Munich, Germany

Publications:

Fendt, S.-M.; Oliveira, A. P.; Christen, S.; Picotti, P.; Dechant, R. C. and Sauer, U.: Unraveling condition-dependent networks of transcription factors that control metabolic pathway activity in yeast. Molecular Systems Biology; 2010, 6:432

Fendt, S.-M.; Buscher, J. M.; Rudroff, F.; Picotti, P.; Zamboni, N. and Sauer, U.: Tradeoff between enzyme and metabolite efficiency maintains metabolic homeostasis upon perturbations in enzyme capacity. Molecular Systems Biology; 2010, 6:356

Kummel, A.; Ewald, J. C.; Fendt, S.-M.; Jol, S. J.; Picotti, P.; Aebersold, R.; Sauer, U.; Zamboni, N. and Heinemann M.: Differential glucose repression in common yeast strains in response to HXK2 deletions. FEMS Yeast Research; 2010, 10(3):322-32

Fendt, S.-M. and Sauer, U.: Transcriptional regulation of respiration in yeast metabolizing differently repressive carbon substrates. BMC Systems Biology; 2010; 4:12

Zamboni, N.; Fendt, S.-M.; Ruhl, M. and Sauer, U.: 13C-based metabolic flux analysis. Nature Protocols; 2009, 4(6):878-892