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Sarah-Maria Fendt

Sarah-Maria Fendt

Postdoctoral Fellow


During my PhD I studied the transcriptional regulation of metabolism in yeast. My postdoctoral work is focused on the elucidation of metabolic alterations in cancer cells. As readout I measure cell physiology, carbon source distribution, and regulator activity in cells harboring various gene mutations and deletions.


2009 Ph.D. ETH Zurich, Switzerland

2005 M.Sc. TU Munich, Germany

2003 B.Sc. TU Munich, Germany


Fendt, S.-M.; Oliveira, A. P.; Christen, S.; Picotti, P.; Dechant, R. C. and Sauer, U.: Unraveling condition-dependent networks of transcription factors that control metabolic pathway activity in yeast. Molecular Systems Biology; 2010, 6:432

Fendt, S.-M.; Buscher, J. M.; Rudroff, F.; Picotti, P.; Zamboni, N. and Sauer, U.: Tradeoff between enzyme and metabolite efficiency maintains metabolic homeostasis upon perturbations in enzyme capacity. Molecular Systems Biology; 2010, 6:356

Kummel, A.; Ewald, J. C.; Fendt, S.-M.; Jol, S. J.; Picotti, P.; Aebersold, R.; Sauer, U.; Zamboni, N. and Heinemann M.: Differential glucose repression in common yeast strains in response to HXK2 deletions. FEMS Yeast Research; 2010, 10(3):322-32

Fendt, S.-M. and Sauer, U.: Transcriptional regulation of respiration in yeast metabolizing differently repressive carbon substrates. BMC Systems Biology; 2010; 4:12

Zamboni, N.; Fendt, S.-M.; Ruhl, M. and Sauer, U.: 13C-based metabolic flux analysis. Nature Protocols; 2009, 4(6):878-892