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Haoran Zhang

Postdoctoral Associate


Research Interests

Metabolic Engineering, Biotechnology, Applied Microbiology


• Ph. D., Chemical Engineering, Tufts University, MA, USA 2005-2010

• M. S., Chemical Engineering, Xiamen University, Fujian, China 2002-2005

• B. S., Chemical Engineering, Xiamen University, Fujian, China 1998-2002


• Haoran Zhang, Zhengjun Li, Brian Pereira, Gregory Stephanopoulos. Engineering E. coli-E. coli cocultures for production of muconic acid from glycerol. Microbial Cell Factories. In press.

• Brian Pereira, Haoran Zhang, Marjan De Mey, Chin Giaw Lim, Zhengjun Li, Gregory Stephanopoulos. Engineering a novle biosynthetic pathway in Escherichia coli for production of renewable ethylene glycol. Biotechnology and Bioengineering. In press.

• Haoran Zhang, Brian Pereira, Zhengjun Li, Gregory Stephanopoulos. Engineering Escherichia coli coculture systems for the production of biochemical products. Proceedings of the National Academy of Sciences of the United States of America. 2015. 112: 8266-8271.

• Kangjian Qiao, Syed Abidi, Hongjuan Liu, Haoran Zhang, Sagar Chakraborty, Nicki Watson, Parayil Kumaran Ajikumar, Gregory Stephanopoulos. Engineering lipid overproduction in the oleaginous yeast Yarrowia lipolytica. Metabolic Engineering. 2015. 29:56-65.

• Ming Jiang, Haoran Zhang, Sung-Hee Park, Yi Li, Blaine Pfeifer. Deoxysugar Pathway Interchange for Erythromycin Analogues Heterologously Produced through E. coli. Metabolic Engineering. 2013. 20:92-100.

• Haoran Zhang, Gregory Stephanopoulos. Engineering E. coli for caffeic acid biosynthesis from renewable sugars. Applied Microbiology and Biotechnology. 2013. 97(8):3333-3341.

• Ming Jiang, Haoran Zhang, Blaine Pfeifer. The Logic, Experimental Steps, and Potential of Heterologous Natural Product Biosynthesis Featuring the Complex Antibiotic Erythromycin A Produced Through E. coli. The Journal of Visualized Experiments. 2013. (71): e4346.

• Haoran Zhang, Karin Skalina, Ming Jiang, Blaine A. Pfeifer. Improved E. coli erythromycin a production through the application of metabolic and bioprocess engineering. Biotechnology Progress. 2012. 28(1): 292-296.

• Haoran Zhang, Brett A. Boghigian, John Armando, Blaine A. Pfeifer. Methods and Options for the Heterologous Production of Complex Natural Products. Natural Product Reports. 2011. 28(1):125-151.

• Brett A. Boghigian, Haoran Zhang, Blaine A. Pfeifer. Multi-factorial engineering of heterologous polyketide production in Escherichia coli reveals complex pathway interactions. Biotechnology and Bioengineering. 2011. 108(6): 1360-1371.

• Haoran Zhang, Yong Wang, Jiequn Wu, Blaine A. Pfeifer. Complete Biosynthesis of Erythromycin A and Designed Analogs Using E. coli as a Heterologous Host. Chemistry and Biology. 2010.17: 1232-1240.

• Jiequn Wu, Brett A. Boghigian, Melissa Myint, Haoran Zhang, Blaine A. Pfeifer. Construction and performance of heterologous polyketide producing K-12 and B-derived Escherichia coli. Letters in Applied Microbiology. 2010. 51: 196–204.

• Haoran Zhang, Brett A. Boghigian, Blaine A. Pfeifer. Investigating the role of native propionyl-CoA and methylmalonyl-CoA metabolism on heterologous polyketide production in Escherichia coli. Biotechnology and Bioengineering. 2010. 105(3): 567-573.

• Haoran Zhang, Yong Wang, Brett A. Boghigian, Blaine A. Pfeifer. Probing the heterologous metabolism supporting 6-deoxyerythronolide B biosynthesis in Escherichia coli. Microbial Biotechnology. 2009. 2(3): 390-394.

• Haoran Zhang, Yong Wang, Blaine A. Pfeifer. Bacterial hosts for natural product production. Molecular Pharmaceutics. 2008. 5(2): 212-225.

• Haoran Zhang, Qingbiao Li, Huixuan Wang, Daohua Sun, Yinghua Lu, Ning He. Accumulation of silver(I) ion and diamine silver complex by Aeromonas SH10 biomass. Applied Biochemistry and Biotechnology. 2007. 143: 54-62.

• Haoran Zhang, Qingbiao Li, Yinghua Lu, Xueping Lin, Xu Deng, Ning He, Shuzhen Zheng. Biosorption and bioreduction of diamine silver complex by Corynebacterium. Journal of Chemical Technology & Biotechnology. 2005. 80(3): 285-290.

• Haoran Zhang, Qingbiao Li, Daohua Sun, Xueping Lin, Xu Deng, Yinghua Lu, Ning He. Preparation of silver nanoparticles. Precious Metals. 2005. 26(2): 51-56.