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Haoran Zhang

Postdoctoral Associate

Email: zhanghr@mit.edu

Research Interest

Metabolic Engineering, Biotechnology

Education

• Ph. D., Chemical Engineering, Tufts University, MA, USA 2005-2010

• M. S., Chemical Engineering, Xiamen University, Fujian, China 2002-2005

• B. S., Chemical Engineering, Xiamen University, Fujian, China 1998-2002

Publications

• Ming Jiang, Haoran Zhang, Sung-Hee Park, Yi Li, Blaine Pfeifer. Deoxysugar Pathway Interchange for Erythromycin Analogues Heterologously Produced through E. coli. Metabolic Engineering. In press.

• Haoran Zhang, Gregory Stephanopoulos. Engineering E. coli for caffeic acid biosynthesis from renewable sugars. Applied Microbiology and Biotechnology. 2013. 97(8):3333-3341.

• Ming Jiang, Haoran Zhang, Blaine Pfeifer. The Logic, Experimental Steps, and Potential of Heterologous Natural Product Biosynthesis Featuring the Complex Antibiotic Erythromycin A Produced Through E. coli. The Journal of Visualized Experiments. 2013. (71): e4346.

• Haoran Zhang, Karin Skalina, Ming Jiang, Blaine A. Pfeifer. Improved E. coli erythromycin a production through the application of metabolic and bioprocess engineering. Biotechnology Progress. 2012. 28(1): 292-296.

• Haoran Zhang, Brett A. Boghigian, John Armando, Blaine A. Pfeifer. Methods and Options for the Heterologous Production of Complex Natural Products. Natural Product Reports. 2011. 28(1):125-151.

• Brett A. Boghigian, Haoran Zhang, Blaine A. Pfeifer. Multi-factorial engineering of heterologous polyketide production in Escherichia coli reveals complex pathway interactions. Biotechnology and Bioengineering. 2011. 108(6): 1360-1371.

• Haoran Zhang, Yong Wang, Jiequn Wu, Blaine A. Pfeifer. Complete Biosynthesis of Erythromycin A and Designed Analogs Using E. coli as a Heterologous Host. Chemistry and Biology. 2010.17: 1232-1240.

• Jiequn Wu, Brett A. Boghigian, Melissa Myint, Haoran Zhang, Blaine A. Pfeifer. Construction and performance of heterologous polyketide producing K-12 and B-derived Escherichia coli. Letters in Applied Microbiology. 2010. 51: 196–204.

• Haoran Zhang, Brett A. Boghigian, Blaine A. Pfeifer. Investigating the role of native propionyl-CoA and methylmalonyl-CoA metabolism on heterologous polyketide production in Escherichia coli. Biotechnology and Bioengineering. 2010. 105(3): 567-573.

• Haoran Zhang, Yong Wang, Brett A. Boghigian, Blaine A. Pfeifer. Probing the heterologous metabolism supporting 6-deoxyerythronolide B biosynthesis in Escherichia coli. Microbial Biotechnology. 2009. 2(3): 390-394.

• Haoran Zhang, Yong Wang, Blaine A. Pfeifer. Bacterial hosts for natural product production. Molecular Pharmaceutics. 2008. 5(2): 212-225.

• Haoran Zhang, Qingbiao Li, Huixuan Wang, Daohua Sun, Yinghua Lu, Ning He. Accumulation of silver(I) ion and diamine silver complex by Aeromonas SH10 biomass. Applied Biochemistry and Biotechnology. 2007. 143: 54-62.

• Haoran Zhang, Qingbiao Li, Yinghua Lu, Xueping Lin, Xu Deng, Ning He, Shuzhen Zheng. Biosorption and bioreduction of diamine silver complex by Corynebacterium. Journal of Chemical Technology & Biotechnology. 2005. 80(3): 285-290.

• Haoran Zhang, Qingbiao Li, Daohua Sun, Xueping Lin, Xu Deng, Yinghua Lu, Ning He. Preparation of silver nanoparticles. Precious Metals. 2005. 26(2): 51-56.