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Peng Xu

Contact information

Email: pengxu@mit.edu

Department of Chemical engineering, Bldg. 56, Room 422, Massachusetts Institute of Technology

Research interest

Metabolic engineering; Pathway optimization and genome engineering; Bioprocess optimization and modeling; Industrial microbiology

Education

2013              PhD in Chemical Engineering, Rensselaer Polytechnic Institute, NY, USA

2006              MS in Biochemical Engineering, Jiangnan University, Wuxi, China

2003              BS in Biological Engineering, Jiangnan University, Wuxi, China

Publications

Please refer to Google Scholar for full list of publications and citations

  1. Trantas EA, Xu P, Koffas MA and Ververidis F. (2014) Biotechnology of Flavonoids: Metabolic engineering with commercial applications when plants produce not enough or at all.  Frontiers in Plant Science.
  2. Xu P, Li L, Zhang F, Stephanopoulos GN and Koffas MA. (2014) Improving fatty acids production by engineering dynamic pathway regulation and metabolic control. Proceedings of the National Academy of Sciences, 111(31):11299-304. [link]
  3. Xu P, Wang W, Li L, Zhang F, Bhan N and Koffas MA. (2014) Design and kinetic analysis of a hybrid promoter-regulator system for malonyl-CoA sensing in E. coli. ACS Chemical Biology, 9(2): 451-458. [link]
  4. Wang W, Englaender J, Xu P, Linhardt RJ, Koffas MA. (2013) Expression of low endotoxin 3-O-sulfotransferase in B. subtilis and B. megaterium. Applied Biochemistry and Biotechnology, 171(4): 954-962. [link]
  5. Bhan N, Xu P and Koffas MA. (2013) Pathway and protein engineering approaches to produce novel and commodity small molecules. Current Opinion in Biotechnology, 24(6): 1137-1143. [link]
  6. Xu P, Gu Q; Wang W, Wong L, Bower A, Collins CH and Koffas MA. (2013) Modular optimization of multi-gene pathway for fatty acids production in E. coli. Nature Communications, 4: 1409. [link]
  7. Xu P, Vansiri A, Bhan N and Koffas MA. (2012) ePathBrick: A synthetic biology platform for engineering metabolic pathways in E. coli. ACS Synthetic Biology, 1(7):256–266. [link]
  8. Xu P, Bhan N and Koffas MA. (2013) Engineering plant metabolism into microbes: from systems biology to synthetic biology. Current Opinion in Biotechnology. 24(2): 291-299. [link]
  9. Bhan N, Xu P, Khalidi O and Koffas MA. (2013) Redirecting carbon flux into Malonyl-CoA to improve Resveratrol titers: Proof of concept for genetic interventions predicted by OptForce computational framework. Chemical Engineering Science, 103: 109-114. [link]

10.  Xu P and Koffas MA. (2013) Assembly of multi-gene pathways and combinatorial pathway libraries through ePathBrick vectors. Methods in Molecular Biology: Synthetic Biology. [link]

11.  Xu P, Ranganathan S, Fowler Z, Maranas CD and Koffas MA. (2011) Genome-scale metabolic network modeling results in minimal interventions that cooperatively force carbon flux towards malonyl-CoA. Metabolic Engineering, 13(5): 578-587. [link]

12.  Zhang L, Ding Z, Xu P et al. (2011) Methyl lucidenate F isolated from the ethanol-soluble-acidic components of Ganoderma lucidum is a novel tyrosinase inhibitor. Biotechnology and Bioprocess Engineering, 16(3): 457-461. [link]

13.  Xu P and Koffas MA. (2010) Metabolic engineering of Escherichia coli for biofuel production, Biofuels, 1(3): 493-504. [link]

14.  Xu P, Ding Z, Qian Z, Zhang K and Zhao C. (2008) Improved production of mycelial biomass and ganoderic acid by submerged culture of Ganoderma lucidum SB97 using complex media. Enzyme and Microbial Technology, 42(4): 325-331. [link]

15.  Xu P, Qian Z, Zhao CX et al. (2008) Kinetic analysis of exo-polysaccharide and ganoderic acid production by submerged culture of Ganoderma lucidum. Chinese Journal of Applied & Environmental Biology, 14(4): 562-565.