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Publications

Books

  1. Gregory N. Stephanopoulos, Aristos A. Aristidou, Jens Nielsen. Metabolic engineering. San Diego: Academic Press, 1998. isbn:0126662606. [1B]
  2. edited by Isidore Rigoutsos and Gregory Stephanopoulos. Systems biology. New York: Oxford University Press, 2007. isbn:0195300815. [2B]
  3. edited by Isidore Rigoutsos and Gregory Stephanopoulos. Systems biology. New York: Oxford University Press, 2007. isbn:0195300807. [3B]

Publications accessible in PubMed

  1. Zhang H, Stephanopoulos G. Engineering E. coli for caffeic acid biosynthesis from renewable sugars. Applied Microbiology and Biotechnology. In press.
  2. Zhou H, Cheng JS, Wang B, Fink GR, Stephanopoulos G. Xylose isomerase overexpression along with engineering of the pentose phosphate pathway and evolutionary engineering enable rapid xylose utilization and ethanol production by Saccharomyces cerevisiae. Metab Eng 2012; 14(6) 611-622 PMID:22921355. PubMed HubMed [156]
  3. Tyo KE, Nevoigt E, Stephanopoulos G. Directed evolution of promoters and tandem gene arrays for customizing RNA synthesis rates and regulation. Methods Enzymol. 2011;497:135-55. PMID:21601085.
  4. Tyo KE, Fischer CR, Simeon F, and Stephanopoulos G. Analysis of polyhydroxybutyrate flux limitations by systematic genetic and metabolic perturbations. Metab Eng 2010 May; 12(3) 187-95.doi:10.1016/j.ymben.2009.10.005 pmid:19879956. PubMed HubMed [155]
  5. Shukla A, Fleming KE, Chuang HF, Chau TM, Loose CR, Stephanopoulos GN, and Hammond PT.Controlling the release of peptide antimicrobial agents from surfaces. Biomaterials 2010 Mar; 31(8) 2348-57. doi:10.1016/j.biomaterials.2009.11.082 pmid:20004967. PubMed HubMed [154]
  6. Klein-Marcuschamer D, Yadav VG, Ghaderi A, and Stephanopoulos GN. De novo metabolic engineering and the promise of synthetic DNA. Adv Biochem Eng Biotechnol 2010; 120 101-31.doi:10.1007/10_2009_52 pmid:20186529. PubMed HubMed [153]
  7. Noguchi Y, Young JD, Aleman JO, Hansen ME, Kelleher JK, and Stephanopoulos G. Effect of anaplerotic fluxes and amino acid availability on hepatic lipoapoptosis. J Biol Chem 2009 Nov 27; 284(48) 33425-36. doi:10.1074/jbc.M109.049478 pmid:19758988. PubMed HubMed [152]
  8. Metallo CM, Walther JL, and Stephanopoulos G. Evaluation of 13C isotopic tracers for metabolic flux analysis in mammalian cells. J Biotechnol 2009 Nov; 144(3) 167-74.doi:10.1016/j.jbiotec.2009.07.010 pmid:19622376. PubMed HubMed [151]
  9. Alper H and Stephanopoulos G. Engineering for biofuels: exploiting innate microbial capacity or importing biosynthetic potential?. Nat Rev Microbiol 2009 Oct; 7(10) 715-23.doi:10.1038/nrmicro2186 pmid:19756010. PubMed HubMed [150]
  10. Tyo KE, Jin YS, Espinoza FA, and Stephanopoulos G. Identification of gene disruptions for increased poly-3-hydroxybutyrate accumulation in Synechocystis PCC 6803. Biotechnol Prog 2009 Sep-Oct; 25(5) 1236-43. doi:10.1002/btpr.228 pmid:19606467. PubMed HubMed [149]
  11. Evans HL, Cuschieri J, Moore EE, Shapiro MB, Nathens AB, Johnson JL, Harbrecht BG, Minei JP, Bankey PE, Maier RV, West MA, and Inflammation and Host Response to Injury Investigators.Inflammation and the host response to injury, a Large-Scale Collaborative Project: patient-oriented research core standard operating procedures for clinical care IX. Definitions for complications of clinical care of critically injured patients. J Trauma 2009 Aug; 67(2) 384-8.doi:10.1097/TA.0b013e3181ad66a7 pmid:19667895. PubMed HubMed [148]
  12. Tyo KE, Ajikumar PK, and Stephanopoulos G. Stabilized gene duplication enables long-term selection-free heterologous pathway expression. Nat Biotechnol 2009 Aug; 27(8) 760-5.doi:10.1038/nbt.1555 pmid:19633654. PubMed HubMed [147]
  13. Klein-Marcuschamer D, Santos CN, Yu H, and Stephanopoulos G. Mutagenesis of the bacterial RNA polymerase alpha subunit for improvement of complex phenotypes. Appl Environ Microbiol 2009 May; 75(9) 2705-11. doi:10.1128/AEM.01888-08 pmid:19251886. PubMed HubMed [146]
  14. Moxley JF, Jewett MC, Antoniewicz MR, Villas-Boas SG, Alper H, Wheeler RT, Tong L, Hinnebusch AG, Ideker T, Nielsen J, and Stephanopoulos G. Linking high-resolution metabolic flux phenotypes and transcriptional regulation in yeast modulated by the global regulator Gcn4p. Proc Natl Acad Sci U S A 2009 Apr 21; 106(16) 6477-82. doi:10.1073/pnas.0811091106 pmid:19346491.PubMed HubMed [145]
  15. Yu H, Tyo K, Alper H, Klein-Marcuschamer D, and Stephanopoulos G. A high-throughput screen for hyaluronic acid accumulation in recombinant Escherichia coli transformed by libraries of engineered sigma factors. Biotechnol Bioeng 2008 Nov 1; 101(4) 788-96. doi:10.1002/bit.21947 pmid:18500764.PubMed HubMed [144]
  16. Stephanopoulos G. Metabolic engineering: enabling technology for biofuels production. Metab Eng 2008 Nov; 10(6) 293-4. doi:10.1016/j.ymben.2008.10.003 pmid:19059122. PubMed HubMed [143]
  17. Fischer CR, Klein-Marcuschamer D, and Stephanopoulos G. Selection and optimization of microbial hosts for biofuels production. Metab Eng 2008 Nov; 10(6) 295-304.doi:10.1016/j.ymben.2008.06.009 pmid:18655844. PubMed HubMed [142]
  18. Yoo H, Antoniewicz MR, Stephanopoulos G, and Kelleher JK. Quantifying reductive carboxylation flux of glutamine to lipid in a brown adipocyte cell line. J Biol Chem 2008 Jul 25; 283(30) 20621-7.doi:10.1074/jbc.M706494200 pmid:18364355. PubMed HubMed [141]
  19. Alper H and Stephanopoulos G. Uncovering the gene knockout landscape for improved lycopene production in E. coli. Appl Microbiol Biotechnol 2008 Apr; 78(5) 801-10. doi:10.1007/s00253-008-1373-x pmid:18239914. PubMed HubMed [140]
  20. Santos CN and Stephanopoulos G. Combinatorial engineering of microbes for optimizing cellular phenotype. Curr Opin Chem Biol 2008 Apr; 12(2) 168-76. doi:10.1016/j.cbpa.2008.01.017 pmid:18275860. PubMed HubMed [139]
  21. Ajikumar PK, Tyo K, Carlsen S, Mucha O, Phon TH, and Stephanopoulos G. Terpenoids: opportunities for biosynthesis of natural product drugs using engineered microorganisms. Mol Pharm 2008 Mar-Apr; 5(2) 167-90. doi:10.1021/mp700151b pmid:18355030. PubMed HubMed [138]
  22. Styczynski MP, Jensen KL, Rigoutsos I, and Stephanopoulos G. BLOSUM62 miscalculations improve search performance. Nat Biotechnol 2008 Mar; 26(3) 274-5. doi:10.1038/nbt0308-274 pmid:18327232. PubMed HubMed [137]
  23. Klein-Marcuschamer D and Stephanopoulos G. Assessing the potential of mutational strategies to elicit new phenotypes in industrial strains. Proc Natl Acad Sci U S A 2008 Feb 19; 105(7) 2319-24.doi:10.1073/pnas.0712177105 pmid:18252819. PubMed HubMed [136]
  24. Young JD, Walther JL, Antoniewicz MR, Yoo H, and Stephanopoulos G. An elementary metabolite unit (EMU) based method of isotopically nonstationary flux analysis. Biotechnol Bioeng 2008 Feb 15; 99(3) 686-99. doi:10.1002/bit.21632 pmid:17787013. PubMed HubMed [135]
  25. Santos CN and Stephanopoulos G. Melanin-based high-throughput screen for L-tyrosine production in Escherichia coli. Appl Environ Microbiol 2008 Feb; 74(4) 1190-7. doi:10.1128/AEM.02448-07 pmid:18156325. PubMed HubMed [134]
  26. Yu H and Stephanopoulos G. Metabolic engineering of Escherichia coli for biosynthesis of hyaluronic acid. Metab Eng 2008 Jan; 10(1) 24-32. doi:10.1016/j.ymben.2007.09.001 pmid:17959405. PubMed HubMed [133]
  27. Ng JK, Ajikumar PK, Tang YC, Lee JY, Stephanopoulos G, and Too HP. Spatially addressable protein array: ssDNA-directed assembly for antibody microarray. Electrophoresis 2007 Dec; 28(24) 4638-44. doi:10.1002/elps.200700183 pmid:18008302. PubMed HubMed [132]
  28. Antoniewicz MR, Kelleher JK, and Stephanopoulos G. Accurate assessment of amino acid mass isotopomer distributions for metabolic flux analysis. Anal Chem 2007 Oct 1; 79(19) 7554-9.doi:10.1021/ac0708893 pmid:17822305. PubMed HubMed [131]
  29. Ng JK, Ajikumar PK, Stephanopoulos G, and Too HP. Profiling RNA polymerase-promoter interaction by using ssDNA-dsDNA probe on a surface addressable microarray. Chembiochem 2007 Sep 24; 8(14) 1667-70. doi:10.1002/cbic.200700340 pmid:17705343. PubMed HubMed [130]
  30. Misra J, Alevizos I, Hwang D, Stephanopoulos G, and Stephanopoulos G. Linking physiology and transcriptional profiles by quantitative predictive models. Biotechnol Bioeng 2007 Sep 1; 98(1) 252-60. doi:10.1002/bit.21540 pmid:17551988. PubMed HubMed [129]
  31. Klein-Marcuschamer D, Ajikumar PK, and Stephanopoulos G. Engineering microbial cell factories for biosynthesis of isoprenoid molecules: beyond lycopene. Trends Biotechnol 2007 Sep; 25(9) 417-24. doi:10.1016/j.tibtech.2007.07.006 pmid:17681626. PubMed HubMed [128]
  32. Alevizos I, Misra J, Bullen J, Basso G, Kelleher J, Mantzoros C, and Stephanopoulos G. Linking hepatic transcriptional changes to high-fat diet induced physiology for diabetes-prone and obese-resistant mice. Cell Cycle 2007 Jul 1; 6(13) 1631-8. pmid:17603298. PubMed HubMed [127]
  33. Antoniewicz MR, Kraynie DF, Laffend LA, González-Lergier J, Kelleher JK, and Stephanopoulos G.Metabolic flux analysis in a nonstationary system: fed-batch fermentation of a high yielding strain of E. coli producing 1,3-propanediol. Metab Eng 2007 May; 9(3) 277-92.doi:10.1016/j.ymben.2007.01.003 pmid:17400499. PubMed HubMed [126]
  34. Alper H and Stephanopoulos G. Global transcription machinery engineering: a new approach for improving cellular phenotype. Metab Eng 2007 May; 9(3) 258-67. doi:10.1016/j.ymben.2006.12.002 pmid:17292651. PubMed HubMed [125]
  35. Ajikumar PK, Ng JK, Tang YC, Lee JY, Stephanopoulos G, and Too HP. Carboxyl-terminated dendrimer-coated bioactive interface for protein microarray: high-sensitivity detection of antigen in complex biological samples. Langmuir 2007 May 8; 23(10) 5670-7. doi:10.1021/la063717u pmid:17388617. PubMed HubMed [124]
  36. Lütke-Eversloh T and Stephanopoulos G. L-tyrosine production by deregulated strains of Escherichia coli. Appl Microbiol Biotechnol 2007 May; 75(1) 103-10. doi:10.1007/s00253-006-0792-9 pmid:17221195. PubMed HubMed [123]
  37. Taniguchi CM, Aleman JO, Ueki K, Luo J, Asano T, Kaneto H, Stephanopoulos G, Cantley LC, and Kahn CR. The p85alpha regulatory subunit of phosphoinositide 3-kinase potentiates c-Jun N-terminal kinase-mediated insulin resistance. Mol Cell Biol 2007 Apr; 27(8) 2830-40.doi:10.1128/MCB.00079-07 pmid:17283057. PubMed HubMed [122]
  38. Jin YS and Stephanopoulos G. Multi-dimensional gene target search for improving lycopene biosynthesis in Escherichia coli. Metab Eng 2007 Jul; 9(4) 337-47.doi:10.1016/j.ymben.2007.03.003 pmid:17509919. PubMed HubMed [121]
  39. Loose CR, Langer RS, and Stephanopoulos GN. Optimization of protein fusion partner length for maximizing in vitro translation of peptides. Biotechnol Prog 2007 Mar-Apr; 23(2) 444-51.doi:10.1021/bp060277o pmid:17269789. PubMed HubMed [120]
  40. Tyo KE, Alper HS, and Stephanopoulos GN. Expanding the metabolic engineering toolbox: more options to engineer cells. Trends Biotechnol 2007 Mar; 25(3) 132-7.doi:10.1016/j.tibtech.2007.01.003 pmid:17254656. PubMed HubMed [119]
  41. Nevoigt E, Fischer C, Mucha O, Matthäus F, Stahl U, and Stephanopoulos G. Engineering promoter regulation. Biotechnol Bioeng 2007 Feb 15; 96(3) 550-8. doi:10.1002/bit.21129 pmid:16964624. PubMed HubMed [118]
  42. Stephanopoulos G. Challenges in engineering microbes for biofuels production. Science 2007 Feb 9; 315(5813) 801-4. doi:10.1126/science.1139612 pmid:17289987. PubMed HubMed [117]
  43. Styczynski MP, Moxley JF, Tong LV, Walther JL, Jensen KL, and Stephanopoulos GN.Systematic identification of conserved metabolites in GC/MS data for metabolomics and biomarker discovery. Anal Chem 2007 Feb 1; 79(3) 966-73. doi:10.1021/ac0614846 pmid:17263323. PubMedHubMed [116]
  44. Antoniewicz MR, Kelleher JK, and Stephanopoulos G. Elementary metabolite units (EMU): a novel framework for modeling isotopic distributions. Metab Eng 2007 Jan; 9(1) 68-86.doi:10.1016/j.ymben.2006.09.001 pmid:17088092. PubMed HubMed [115]
  45. Alper H, Moxley J, Nevoigt E, Fink GR, and Stephanopoulos G. Engineering yeast transcription machinery for improved ethanol tolerance and production. Science 2006 Dec 8; 314(5805) 1565-8.doi:10.1126/science.1131969 pmid:17158319. PubMed HubMed [114]
  46. Loose C, Jensen K, Rigoutsos I, and Stephanopoulos G. A linguistic model for the rational design of antimicrobial peptides. Nature 2006 Oct 19; 443(7113) 867-9. doi:10.1038/nature05233 pmid:17051220. PubMed HubMed [113]
  47. Alper H, Miyaoku K, and Stephanopoulos G. Characterization of lycopene-overproducing E. coli strains in high cell density fermentations. Appl Microbiol Biotechnol 2006 Oct; 72(5) 968-74.doi:10.1007/s00253-006-0357-y pmid:16502313. PubMed HubMed [112]
  48. Nevoigt E, Kohnke J, Fischer CR, Alper H, Stahl U, and Stephanopoulos G. Engineering of promoter replacement cassettes for fine-tuning of gene expression in Saccharomyces cerevisiae.Appl Environ Microbiol 2006 Aug; 72(8) 5266-73. doi:10.1128/AEM.00530-06 pmid:16885275.PubMed HubMed [111]
  49. Antoniewicz MR, Kelleher JK, and Stephanopoulos G. Determination of confidence intervals of metabolic fluxes estimated from stable isotope measurements. Metab Eng 2006 Jul; 8(4) 324-37.doi:10.1016/j.ymben.2006.01.004 pmid:16631402. PubMed HubMed [110]
  50. Styczynski MP, Fischer CR, and Stephanopoulos GN. The intelligent design of evolution. Mol Syst Biol 2006; 2 2006.0020. doi:10.1038/msb4100065 pmid:16738565. PubMed HubMed [109]
  51. Jensen K, Alper H, Fischer C, and Stephanopoulos G. Identifying functionally important mutations from phenotypically diverse sequence data. Appl Environ Microbiol 2006 May; 72(5) 3696-701.doi:10.1128/AEM.72.5.3696-3701.2006 pmid:16672519. PubMed HubMed [108]
  52. Tyo KE, Zhou H, and Stephanopoulos GN. High-throughput screen for poly-3-hydroxybutyrate in Escherichia coli and Synechocystis sp. strain PCC6803. Appl Environ Microbiol 2006 May; 72(5) 3412-7. doi:10.1128/AEM.72.5.3412-3417.2006 pmid:16672485. PubMed HubMed [107]
  53. Antoniewicz MR, Stephanopoulos G, and Kelleher JK. Evaluation of regression models in metabolic physiology: predicting fluxes from isotopic data without knowledge of the pathway. Metabolomics 2006 Mar; 2(1) 41-52. doi:10.1007/s11306-006-0018-2 pmid:17066125. PubMed HubMed [106]
  54. Fischer CR, Alper H, Nevoigt E, Jensen KL, and Stephanopoulos G. Response to Hammer et al.: Tuning genetic control–importance of thorough promoter characterization versus generating promoter diversity. Trends Biotechnol 2006 Feb; 24(2) 55-6. doi:10.1016/j.tibtech.2005.12.001 pmid:16380177. PubMed HubMed [105]
  55. Jensen KL, Styczynski MP, Rigoutsos I, and Stephanopoulos GN. A generic motif discovery algorithm for sequential data. Bioinformatics 2006 Jan 1; 22(1) 21-8.doi:10.1093/bioinformatics/bti745 pmid:16257985. PubMed HubMed [104]
  56. Raab RM, Tyo K, and Stephanopoulos G. Metabolic engineering. Adv Biochem Eng Biotechnol 2005; 100 1-17. pmid:16270654. PubMed HubMed [103]
  57. Jin YS, Alper H, Yang YT, and Stephanopoulos G. Improvement of xylose uptake and ethanol production in recombinant Saccharomyces cerevisiae through an inverse metabolic engineering approach. Appl Environ Microbiol 2005 Dec; 71(12) 8249-56. doi:10.1128/AEM.71.12.8249-8256.2005 pmid:16332810. PubMed HubMed [102]
  58. Stephanopoulos G, Garefalaki ME, and Lyroudia K. Genes and related proteins involved in amelogenesis imperfecta. J Dent Res 2005 Dec; 84(12) 1117-26. pmid:16304440. PubMed HubMed[101]
  59. Lütke-Eversloh T and Stephanopoulos G. Feedback inhibition of chorismate mutase/prephenate dehydrogenase (TyrA) of Escherichia coli: generation and characterization of tyrosine-insensitive mutants. Appl Environ Microbiol 2005 Nov; 71(11) 7224-8. doi:10.1128/AEM.71.11.7224-7228.2005 pmid:16269762. PubMed HubMed [100]
  60. Alper H, Fischer C, Nevoigt E, and Stephanopoulos G. Tuning genetic control through promoter engineering. Proc Natl Acad Sci U S A 2005 Sep 6; 102(36) 12678-83.doi:10.1073/pnas.0504604102 pmid:16123130. PubMed HubMed [99]
  61. Camelo S, Iglesias AH, Hwang D, Due B, Ryu H, Smith K, Gray SG, Imitola J, Duran G, Assaf B, Langley B, Khoury SJ, Stephanopoulos G, De Girolami U, Ratan RR, Ferrante RJ, and Dangond F.Transcriptional therapy with the histone deacetylase inhibitor trichostatin A ameliorates experimental autoimmune encephalomyelitis. J Neuroimmunol 2005 Jul; 164(1-2) 10-21.doi:10.1016/j.jneuroim.2005.02.022 pmid:15885809. PubMed HubMed [98]
  62. Raab RM, Bullen J, Kelleher J, Mantzoros C, and Stephanopoulos G. Regulation of mouse hepatic genes in response to diet induced obesity, insulin resistance and fasting induced weight reduction.Nutr Metab (Lond) 2005 Jun 28; 2 15. doi:10.1186/1743-7075-2-15 pmid:15985155. PubMedHubMed [97]
  63. Koffas M and Stephanopoulos G. Strain improvement by metabolic engineering: lysine production as a case study for systems biology. Curr Opin Biotechnol 2005 Jun; 16(3) 361-6.doi:10.1016/j.copbio.2005.04.010 pmid:15961038. PubMed HubMed [96]
  64. Villas-Bôas SG, Moxley JF, Akesson M, Stephanopoulos G, and Nielsen J. High-throughput metabolic state analysis: the missing link in integrated functional genomics of yeasts. Biochem J 2005 Jun 1; 388(Pt 2) 669-77. doi:10.1042/BJ20041162 pmid:15667247. PubMed HubMed [95]
  65. Alper H, Jin YS, Moxley JF, and Stephanopoulos G. Identifying gene targets for the metabolic engineering of lycopene biosynthesis in Escherichia coli. Metab Eng 2005 May; 7(3) 155-64.doi:10.1016/j.ymben.2004.12.003 pmid:15885614. PubMed HubMed [94]
  66. Alper H, Miyaoku K, and Stephanopoulos G. Construction of lycopene-overproducing E. coli strains by combining systematic and combinatorial gene knockout targets. Nat Biotechnol 2005 May; 23(5) 612-6. doi:10.1038/nbt1083 pmid:15821729. PubMed HubMed [93]
  67. Cobb JP, Mindrinos MN, Miller-Graziano C, Calvano SE, Baker HV, Xiao W, Laudanski K, Brownstein BH, Elson CM, Hayden DL, Herndon DN, Lowry SF, Maier RV, Schoenfeld DA, Moldawer LL, Davis RW, Tompkins RG, Baker HV, Bankey P, Billiar T, Brownstein BH, Calvano SE, Camp D, Chaudry I, Cobb JP, Davis RW, Elson CM, Freeman B, Gamelli R, Gibran N, Harbrecht B, Hayden DL, Heagy W, Heimbach D, Herndon DN, Horton J, Hunt J, Laudanski K, Lederer J, Lowry SF, Maier RV, Mannick J, McKinley B, Miller-Graziano C, Mindrinos MN, Minei J, Moldawer LL, Moore E, Moore F, Munford R, Nathens A, O’keefe G, Purdue G, Rahme L, Remick D, Sailors M, Schoenfeld DA, Shapiro M, Silver G, Smith R, Stephanopoulos G, Stormo G, Tompkins RG, Toner M, Warren S, West M, Wolfe S, Xiao W, Young V, and Inflammation and Host Response to Injury Large-Scale Collaborative Research Program. Application of genome-wide expression analysis to human health and disease. Proc Natl Acad Sci U S A 2005 Mar 29; 102(13) 4801-6. doi:10.1073/pnas.0409768102 pmid:15781863. PubMed HubMed [92]
  68. Styczynski MP, Jensen KL, Rigoutsos I, and Stephanopoulos GN. An extension and novel solution to the (l,d)-motif challenge problem. Genome Inform 2004; 15(2) 63-71. pmid:15706492. PubMedHubMed [91]
  69. Heijnen JJ, van Gulik WM, Shimizu H, and Stephanopoulos G. Metabolic flux control analysis of branch points: an improved approach to obtain flux control coefficients from large perturbation data.Metab Eng 2004 Oct; 6(4) 391-400. doi:10.1016/j.ymben.2004.07.002 pmid:15491867. PubMedHubMed [90]
  70. Stephanopoulos G, Alper H, and Moxley J. Exploiting biological complexity for strain improvement through systems biology. Nat Biotechnol 2004 Oct; 22(10) 1261-7. doi:10.1038/nbt1016 pmid:15470466. PubMed HubMed [89]
  71. Raab RM and Stephanopoulos G. Dynamics of gene silencing by RNA interference. Biotechnol Bioeng 2004 Oct 5; 88(1) 121-32. doi:10.1002/bit.20216 pmid:15389485. PubMed HubMed [88]
  72. Bullen JW Jr, Ziotopoulou M, Ungsunan L, Misra J, Alevizos I, Kokkotou E, Maratos-Flier E, Stephanopoulos G, and Mantzoros CS. Short-term resistance to diet-induced obesity in A/J mice is not associated with regulation of hypothalamic neuropeptides. Am J Physiol Endocrinol Metab 2004 Oct; 287(4) E662-70. doi:10.1152/ajpendo.00114.2004 pmid:15361355. PubMed HubMed [87]
  73. Schmitt WA Jr, Raab RM, and Stephanopoulos G. Elucidation of gene interaction networks through time-lagged correlation analysis of transcriptional data. Genome Res 2004 Aug; 14(8) 1654-63.doi:10.1101/gr.2439804 pmid:15289483. PubMed HubMed [86]
  74. Lynch MD, Gill RT, and Stephanopoulos G. Mapping phenotypic landscapes using DNA micro-arrays. Metab Eng 2004 Jul; 6(3) 177-85. doi:10.1016/j.ymben.2004.01.002 pmid:15256207.PubMed HubMed [85]
  75. Yoo H, Stephanopoulos G, and Kelleher JK. Quantifying carbon sources for de novo lipogenesis in wild-type and IRS-1 knockout brown adipocytes. J Lipid Res 2004 Jul; 45(7) 1324-32.doi:10.1194/jlr.M400031-JLR200 pmid:15102881. PubMed HubMed [84]
  76. Iglesias AH, Camelo S, Hwang D, Villanueva R, Stephanopoulos G, and Dangond F. Microarray detection of E2F pathway activation and other targets in multiple sclerosis peripheral blood mononuclear cells. J Neuroimmunol 2004 May; 150(1-2) 163-77. doi:10.1016/j.jneuroim.2004.01.017 pmid:15081262. PubMed HubMed [83]
  77. Jung GY and Stephanopoulos G. A functional protein chip for pathway optimization and in vitro metabolic engineering. Science 2004 Apr 16; 304(5669) 428-31. doi:10.1126/science.1096920 pmid:15087547. PubMed HubMed [82]
  78. Lee K, Hwang D, Yokoyama T, Stephanopoulos G, Stephanopoulos GN, and Yarmush ML.Identification of optimal classification functions for biological sample and state discrimination from metabolic profiling data. Bioinformatics 2004 Apr 12; 20(6) 959-69.doi:10.1093/bioinformatics/bth015 pmid:14751977. PubMed HubMed [81]
  79. Hwang D, Stephanopoulos G, and Chan C. Inverse modeling using multi-block PLS to determine the environmental conditions that provide optimal cellular function. Bioinformatics 2004 Mar 1; 20(4) 487-99. doi:10.1093/bioinformatics/btg433 pmid:14990444. PubMed HubMed [80]
  80. Dangond F, Hwang D, Camelo S, Pasinelli P, Frosch MP, Stephanopoulos G, Stephanopoulos G, Brown RH Jr, and Gullans SR. Molecular signature of late-stage human ALS revealed by expression profiling of postmortem spinal cord gray matter. Physiol Genomics 2004 Jan 15; 16(2) 229-39. doi:10.1152/physiolgenomics.00087.2001 pmid:14645737. PubMed HubMed [79]
  81. Wong MS, Raab RM, Rigoutsos I, Stephanopoulos GN, and Kelleher JK. Metabolic and transcriptional patterns accompanying glutamine depletion and repletion in mouse hepatoma cells: a model for physiological regulatory networks. Physiol Genomics 2004 Jan 15; 16(2) 247-55.doi:10.1152/physiolgenomics.00088.2003 pmid:14612591. PubMed HubMed [78]
  82. Padilla L, Krämer R, Stephanopoulos G, and Agosin E. Overproduction of trehalose: heterologous expression of Escherichia coli trehalose-6-phosphate synthase and trehalose-6-phosphate phosphatase in Corynebacterium glutamicum. Appl Environ Microbiol 2004 Jan; 70(1) 370-6.pmid:14711665. PubMed HubMed [77]
  83. Schmitt WA Jr and Stephanopoulos G. Prediction of transcriptional profiles of Synechocystis PCC6803 by dynamic autoregressive modeling of DNA microarray data. Biotechnol Bioeng 2003 Dec 30; 84(7) 855-63. doi:10.1002/bit.10843 pmid:14708126. PubMed HubMed [76]
  84. Lee K, Berthiaume F, Stephanopoulos GN, and Yarmush ML. Induction of a hypermetabolic state in cultured hepatocytes by glucagon and H2O2. Metab Eng 2003 Oct; 5(4) 221-9. pmid:14642350.PubMed HubMed [75]
  85. Klapa MI, Aon JC, and Stephanopoulos G. Systematic quantification of complex metabolic flux networks using stable isotopes and mass spectrometry. Eur J Biochem 2003 Sep; 270(17) 3525-42. pmid:12919317. PubMed HubMed [74]
  86. Lee K, Berthiaume F, Stephanopoulos GN, and Yarmush ML. Profiling of dynamic changes in hypermetabolic livers. Biotechnol Bioeng 2003 Aug 20; 83(4) 400-15. doi:10.1002/bit.10682 pmid:12800135. PubMed HubMed [73]
  87. Klapa MI, Aon JC, and Stephanopoulos G. Ion-trap mass spectrometry used in combination with gas chromatography for high-resolution metabolic flux determination. Biotechniques 2003 Apr; 34(4) 832-6, 838, 840 passim. pmid:12703309. PubMed HubMed [72]
  88. Chan C, Hwang D, Stephanopoulos GN, Yarmush ML, and Stephanopoulos G. Application of multivariate analysis to optimize function of cultured hepatocytes. Biotechnol Prog 2003 Mar-Apr; 19(2) 580-98. doi:10.1021/bp025660h pmid:12675604. PubMed HubMed [71]
  89. Hwang D, Alevizos I, Schmitt WA, Misra J, Ohyama H, Todd R, Mahadevappa M, Warrington JA, Stephanopoulos G, Wong DT, and Stephanopoulos G. Genomic dissection for characterization of cancerous oral epithelium tissues using transcription profiling. Oral Oncol 2003 Apr; 39(3) 259-68.pmid:12618198. PubMed HubMed [70]
  90. Varela C, Agosin E, Baez M, Klapa M, and Stephanopoulos G. Metabolic flux redistribution in Corynebacterium glutamicum in response to osmotic stress. Appl Microbiol Biotechnol 2003 Jan; 60(5) 547-55. doi:10.1007/s00253-002-1120-7 pmid:12536254. PubMed HubMed [69]
  91. Koffas MA, Jung GY, and Stephanopoulos G. Engineering metabolism and product formation in Corynebacterium glutamicum by coordinated gene overexpression. Metab Eng 2003 Jan; 5(1) 32-41. pmid:12749842. PubMed HubMed [68]
  92. Koffas MA, Jung GY, Aon JC, and Stephanopoulos G. Effect of pyruvate carboxylase overexpression on the physiology of Corynebacterium glutamicum. Appl Environ Microbiol 2002 Nov; 68(11) 5422-8. pmid:12406733. PubMed HubMed [67]
  93. Hwang D, Schmitt WA, Stephanopoulos G, and Stephanopoulos G. Determination of minimum sample size and discriminatory expression patterns in microarray data. Bioinformatics 2002 Sep; 18(9) 1184-93. pmid:12217910. PubMed HubMed [66]
  94. Stephanopoulos G, Hwang D, Schmitt WA, Misra J, and Stephanopoulos G. Mapping physiological states from microarray expression measurements. Bioinformatics 2002 Aug; 18(8) 1054-63.pmid:12176828. PubMed HubMed [65]
  95. Misra J, Schmitt W, Hwang D, Hsiao LL, Gullans S, Stephanopoulos G, and Stephanopoulos G.Interactive exploration of microarray gene expression patterns in a reduced dimensional space.Genome Res 2002 Jul; 12(7) 1112-20. doi:10.1101/gr.225302 pmid:12097349. PubMed HubMed[64]
  96. Stephanopoulos G. Metabolic engineering by genome shuffling. Nat Biotechnol 2002 Jul; 20(7) 666-8. doi:10.1038/nbt0702-666 pmid:12089547. PubMed HubMed [63]
  97. Gill RT, Katsoulakis E, Schmitt W, Taroncher-Oldenburg G, Misra J, and Stephanopoulos G.Genome-wide dynamic transcriptional profiling of the light-to-dark transition in Synechocystis sp. strain PCC 6803. J Bacteriol 2002 Jul; 184(13) 3671-81. pmid:12057963. PubMed HubMed [62]
  98. Gill RT, Wildt S, Yang YT, Ziesman S, and Stephanopoulos G. Genome-wide screening for trait conferring genes using DNA microarrays. Proc Natl Acad Sci U S A 2002 May 14; 99(10) 7033-8.doi:10.1073/pnas.102154799 pmid:11997466. PubMed HubMed [61]
  99. Stafford DE, Yanagimachi KS, Lessard PA, Rijhwani SK, Sinskey AJ, and Stephanopoulos G.Optimizing bioconversion pathways through systems analysis and metabolic engineering. Proc Natl Acad Sci U S A 2002 Feb 19; 99(4) 1801-6. doi:10.1073/pnas.032681699 pmid:11854482. PubMedHubMed [60]
  100. Follstad BD, Wang DI, and Stephanopoulos G. Mitochondrial membrane potential selects hybridomas yielding high viability in fed-batch cultures. Biotechnol Prog 2002 Jan-Feb; 18(1) 1-5.doi:10.1021/bp010132b pmid:11822893. PubMed HubMed [59]
  101. Walton SP, Stephanopoulos GN, Yarmush ML, and Roth CM. Thermodynamic and kinetic characterization of antisense oligodeoxynucleotide binding to a structured mRNA. Biophys J 2002 Jan; 82(1 Pt 1) 366-77. doi:10.1016/S0006-3495(02)75401-5 pmid:11751323. PubMed HubMed [58]
  102. Stafford DE, Yanagimachi KS, and Stephanopoulos G. Metabolic engineering of indene bioconversion in Rhodococcus sp. Adv Biochem Eng Biotechnol 2001; 73 85-101. pmid:11816813.PubMed HubMed [57]
  103. Stephanopoulos G and Gill RT. After a decade of progress, an expanded role for metabolic engineering. Adv Biochem Eng Biotechnol 2001; 73 1-8. pmid:11816808. PubMed HubMed [56]
  104. Hsiao LL, Dangond F, Yoshida T, Hong R, Jensen RV, Misra J, Dillon W, Lee KF, Clark KE, Haverty P, Weng Z, Mutter GL, Frosch MP, MacDonald ME, Milford EL, Crum CP, Bueno R, Pratt RE, Mahadevappa M, Warrington JA, Stephanopoulos G, Stephanopoulos G, and Gullans SR. A compendium of gene expression in normal human tissues. Physiol Genomics 2001 Dec 21; 7(2) 97-104. doi:10.1152/physiolgenomics.00040.2001 pmid:11773596. PubMed HubMed [55]
  105. Yanagimachi KS, Stafford DE, Dexter AF, Sinskey AJ, Drew S, and Stephanopoulos G. Application of radiolabeled tracers to biocatalytic flux analysis. Eur J Biochem 2001 Sep; 268(18) 4950-60.pmid:11559364. PubMed HubMed [54]
  106. Stephanopoulos G and Kelleher J. Biochemistry. How to make a superior cell. Science 2001 Jun 15; 292(5524) 2024-5. doi:10.1126/science.1062556 pmid:11408647. PubMed HubMed [53]
  107. Balcarcel RR and Stephanopoulos G. Rapamycin reduces hybridoma cell death and enhances monoclonal antibody production. Biotechnol Bioeng 2001; 76(1) 1-10. pmid:11400101. PubMedHubMed [52]
  108. Stafford DE and Stephanopoulos G. Metabolic engineering as an integrating platform for strain development. Curr Opin Microbiol 2001 Jun; 4(3) 336-40. pmid:11378489. PubMed HubMed [51]
  109. Taroncher-Oldenburg G and Stephanopoulos G. Targeted, PCR-based gene disruption in cyanobacteria: inactivation of the polyhydroxyalkanoic acid synthase genes in Synechocystis sp. PCC6803. Appl Microbiol Biotechnol 2000 Nov; 54(5) 677-80. pmid:11131394. PubMed HubMed[50]
  110. Follstad BD, Wang DI, and Stephanopoulos G. Mitochondrial membrane potential differentiates cells resistant to apoptosis in hybridoma cultures. Eur J Biochem 2000 Nov; 267(22) 6534-40.pmid:11054104. PubMed HubMed [49]
  111. Sanfeliu A, Chung JD, and Stephanopoulos G. Effect of insulin stimulation on the proliferation and death of Chinese hamster ovary cells. Biotechnol Bioeng 2000 Nov 20; 70(4) 421-7.pmid:11005924. PubMed HubMed [48]
  112. Taroncher-Oldenburg G, Nishina K, and Stephanopoulos G. Identification and analysis of the polyhydroxyalkanoate-specific beta-ketothiolase and acetoacetyl coenzyme A reductase genes in the cyanobacterium Synechocystis sp. strain PCC6803. Appl Environ Microbiol 2000 Oct; 66(10) 4440-8. pmid:11010896. PubMed HubMed [47]
  113. Lee K, Berthiaume F, Stephanopoulos GN, Yarmush DM, and Yarmush ML. Metabolic flux analysis of postburn hepatic hypermetabolism. Metab Eng 2000 Oct; 2(4) 312-27.doi:10.1006/mben.2000.0160 pmid:11120643. PubMed HubMed [46]
  114. Kamimura RT, Bicciato S, Shimizu H, Alford J, and Stephanopoulos G. Mining of biological data II: assessing data structure and class homogeneity by cluster analysis. Metab Eng 2000 Jul; 2(3) 228-38. doi:10.1006/mben.2000.0155 pmid:11056065. PubMed HubMed [45]
  115. Kamimura RT, Bicciato S, Shimizu H, Alford J, and Stephanopoulos G. Mining of biological data I: identifying discriminating features via mean hypothesis testing. Metab Eng 2000 Jul; 2(3) 218-27.doi:10.1006/mben.2000.0154 pmid:11056064. PubMed HubMed [44]
  116. Stephanopoulos G. Bioinformatics and metabolic engineering. Metab Eng 2000 Jul; 2(3) 157-8.doi:10.1006/mben.2000.0157 pmid:11056058. PubMed HubMed [43]
  117. Shanks JV and Stephanopoulos G. Biochemical engineering. Bridging the gap between gene and product. Curr Opin Biotechnol 2000 Apr; 11(2) 169-70. pmid:10809544. PubMed HubMed [42]
  118. Vallino JJ and Stephanopoulos G. Metabolic flux distributions in Corynebacterium glutamicum during growth and lysine overproduction. Reprinted from Biotechnology and Bioengineering, Vol. 41, Pp 633-646 (1993). Biotechnol Bioeng 2000 Mar 20; 67(6) 872-85. pmid:10699864. PubMedHubMed [41]
  119. Walton SP, Stephanopoulos GN, Yarmush ML, and Roth CM. Prediction of antisense oligonucleotide binding affinity to a structured RNA target. Biotechnol Bioeng 1999 Oct 5; 65(1) 1-9.pmid:10440665. PubMed HubMed [40]
  120. Lee K, Berthiaume F, Stephanopoulos GN, and Yarmush ML. Metabolic flux analysis: a powerful tool for monitoring tissue function. Tissue Eng 1999 Aug; 5(4) 347-68. pmid:10477857. PubMedHubMed [39]
  121. Koffas M, Roberge C, Lee K, and Stephanopoulos G. Metabolic engineering. Annu Rev Biomed Eng 1999; 1 535-57. doi:10.1146/annurev.bioeng.1.1.535 pmid:11701499. PubMed HubMed [38]
  122. Sanfeliu A and Stephanopoulos G. Effect of glutamine limitation on the death of attached Chinese hamster ovary cells. Biotechnol Bioeng 1999 Jul 5; 64(1) 46-53. pmid:10397838. PubMed HubMed[37]
  123. Follstad BD, Balcarcel RR, Stephanopoulos G, and Wang DI. Metabolic flux analysis of hybridoma continuous culture steady state multiplicity. Biotechnol Bioeng 1999 Jun 20; 63(6) 675-83.pmid:10397824. PubMed HubMed [36]
  124. Treadway SL, Yanagimachi KS, Lankenau E, Lessard PA, Stephanopoulos G, and Sinskey AJ.Isolation and characterization of indene bioconversion genes from Rhodococcus strain I24. Appl Microbiol Biotechnol 1999 Jun; 51(6) 786-93. pmid:10422226. PubMed HubMed [35]
  125. Simpson TW, Follstad BD, and Stephanopoulos G. Analysis of the pathway structure of metabolic networks. J Biotechnol 1999 May 28; 71(1-3) 207-23. pmid:10483107. PubMed HubMed [34]
  126. Shaw-Reid CA, McCormick MM, Sinskey AJ, and Stephanopoulos G. Flux through the tetrahydrodipicolinate succinylase pathway is dispensable for L-lysine production in Corynebacterium glutamicum. Appl Microbiol Biotechnol 1999 Mar; 51(3) 325-33. pmid:10222581.PubMed HubMed [33]
  127. Goswami J, Sinskey AJ, Steller H, Stephanopoulos GN, and Wang DI. Apoptosis in batch cultures of Chinese hamster ovary cells. Biotechnol Bioeng 1999 Mar 20; 62(6) 632-40. pmid:9951521.PubMed HubMed [32]
  128. Park SM, Klapa MI, Sinskey AJ, and Stephanopoulos G. Metabolite and isotopomer balancing in the analysis of metabolic cycles: II. Applications. Biotechnol Bioeng 1999 Feb 20; 62(4) 392-401.pmid:9921151. PubMed HubMed [31]
  129. Nyberg GB, Balcarcel RR, Follstad BD, Stephanopoulos G, and Wang DI. Metabolic effects on recombinant interferon-gamma glycosylation in continuous culture of Chinese hamster ovary cells.Biotechnol Bioeng 1999 Feb 5; 62(3) 336-47. pmid:10099545. PubMed HubMed [30]
  130. Nyberg GB, Balcarcel RR, Follstad BD, Stephanopoulos G, and Wang DI. Metabolism of peptide amino acids by Chinese hamster ovary cells grown in a complex medium. Biotechnol Bioeng 1999 Feb 5; 62(3) 324-35. pmid:10099544. PubMed HubMed [29]
  131. Klapa MI, Park SM, Sinskey AJ, and Stephanopoulos G. Metabolite and isotopomer balancing in the analysis of metabolic cycles: I. Theory. Biotechnol Bioeng 1999 Feb; 62(4) 375-391.pmid:10099550. PubMed HubMed [28]
  132. Stephanopoulos G. Metabolic fluxes and metabolic engineering. Metab Eng 1999 Jan; 1(1) 1-11.doi:10.1006/mben.1998.0101 pmid:10935750. PubMed HubMed [27]
  133. Koffas MA, Ramamoorthi R, Pine WA, Sinskey AJ, and Stephanopoulos G. Sequence of the Corynebacterium glutamicum pyruvate carboxylase gene. Appl Microbiol Biotechnol 1998 Sep; 50(3) 346-52. pmid:9802220. PubMed HubMed [26]
  134. Stephanopoulos G. Metabolic engineering. Biotechnol Bioeng 1998 Apr 20-May 5; 58(2-3) 119-20.pmid:10191379. PubMed HubMed [25]
  135. Simpson TW, Shimizu H, and Stephanopoulos G. Experimental determination of group flux control coefficients in metabolic networks. Biotechnol Bioeng 1998 Apr 5; 58(2-3) 149-53. pmid:10191384.PubMed HubMed [24]
  136. Follstad BD and Stephanopoulos G. Effect of reversible reactions on isotope label redistribution–analysis of the pentose phosphate pathway. Eur J Biochem 1998 Mar 15; 252(3) 360-71.pmid:9546650. PubMed HubMed [23]
  137. Chung JD, Sinskey AJ, and Stephanopoulos G. Growth factor and bcl-2 mediated survival during abortive proliferation of hybridoma cell line. Biotechnol Bioeng 1998 Jan 20; 57(2) 164-71.pmid:10099191. PubMed HubMed [22]
  138. Grampp GE, Applegate MA, and Stephanopoulos G. Cyclic operation of ceramic-matrix animal cell bioreactors for controlled secretion of an endocrine hormone. A comparison of single-pass and recycle modes of operation. Biotechnol Prog 1996 Nov-Dec; 12(6) 837-46. doi:10.1021/bp960066r pmid:8983208. PubMed HubMed [21]
  139. Kamimura R, Konstantinov K, and Stephanopoulos G. Knowledge-based systems, artificial neural networks and pattern recognition: applications to biotechnological processes. Curr Opin Biotechnol 1996 Apr; 7(2) 231-4. pmid:8791334. PubMed HubMed [20]
  140. Zupke C, Sinskey AJ, and Stephanopoulos G. Intracellular flux analysis applied to the effect of dissolved oxygen on hybridomas. Appl Microbiol Biotechnol 1995 Dec; 44(1-2) 27-36.pmid:8579834. PubMed HubMed [19]
  141. Chen K, Stephanopoulos GN, Sinskey AJ, and Lodish HF. Regulated secretion of prolactin by the mouse insulinoma cell line beta TC-3. Biotechnology (N Y) 1995 Nov; 13(11) 1191-7. pmid:9636291.PubMed HubMed [18]
  142. Chung JD, Conner S, and Stephanopoulos G. Flow cytometric study of differentiating cultures of Bacillus subtilis. Cytometry 1995 Aug 1; 20(4) 324-33. doi:10.1002/cyto.990200408 pmid:7587720.PubMed HubMed [17]
  143. Colón GE, Nguyen TT, Jetten MS, Sinskey AJ, and Stephanopoulos G. Production of isoleucine by overexpression of ilvA in a Corynebacterium lactofermentum threonine producer. Appl Microbiol Biotechnol 1995 Jul; 43(3) 482-8. pmid:7632398. PubMed HubMed [16]
  144. Simpson TW, Colón GE, and Stephanopoulos G. Two paradigms of metabolic engineering applied to amino acid biosynthesis. Biochem Soc Trans 1995 May; 23(2) 381-7. pmid:7672413. PubMedHubMed [15]
  145. Colón GE, Jetten MS, Nguyen TT, Gubler ME, Follettie MT, Sinskey AJ, and Stephanopoulos G.Effect of inducible thrB expression on amino acid production in Corynebacterium lactofermentum ATCC 21799. Appl Environ Microbiol 1995 Jan; 61(1) 74-8. pmid:7887627. PubMed HubMed [14]
  146. Singhvi R, Kumar A, Lopez GP, Stephanopoulos GN, Wang DI, Whitesides GM, and Ingber DE.Engineering cell shape and function. Science 1994 Apr 29; 264(5159) 696-8. pmid:8171320.PubMed HubMed [13]
  147. Chung JD, Stephanopoulos G, Ireton K, and Grossman AD. Gene expression in single cells of Bacillus subtilis: evidence that a threshold mechanism controls the initiation of sporulation. J Bacteriol 1994 Apr; 176(7) 1977-84. pmid:8144465. PubMed HubMed [12]
  148. Stephanopoulos G. Metabolic engineering. Curr Opin Biotechnol 1994 Feb; 5(2) 196-200.pmid:7764800. PubMed HubMed [11]
  149. Shelikoff M, Sinskey AJ, and Stephanopoulos G. The effect of protein synthesis inhibitors on the glycosylation site occupancy of recombinant human prolactin. Cytotechnology 1994; 15(1-3) 195-208. pmid:7765932. PubMed HubMed [10]
  150. Grampp GE and Stephanopoulos G. Development and scaleup of controlled secretion processes for improved product recovery in animal cell culture. Ann N Y Acad Sci 1992 Oct 13; 665 81-93.pmid:1416622. PubMed HubMed [9]
  151. Kennedy MJ, Thakur MS, Wang DI, and Stephanopoulos GN. Techniques for the estimation of cell concentration in the presence of suspended solids. Biotechnol Prog 1992 Sep-Oct; 8(5) 375-81.doi:10.1021/bp00017a001 pmid:1369219. PubMed HubMed [8]
  152. Stephanopoulos G and Sinskey AJ. Metabolic engineering–methodologies and future prospects.Trends Biotechnol 1993 Sep; 11(9) 392-6. pmid:7764086. PubMed HubMed [7]
  153. Grampp GE, Sambanis A, and Stephanopoulos GN. Use of regulated secretion in protein production from animal cells: an overview. Adv Biochem Eng Biotechnol 1992; 46 35-62.pmid:1636482. PubMed HubMed [6]
  154. Stephanopoulos G and Vallino JJ. Network rigidity and metabolic engineering in metabolite overproduction. Science 1991 Jun 21; 252(5013) 1675-81. pmid:1904627. PubMed HubMed [5]
  155. Sambanis A, Stephanopoulos G, and Lodish HF. Multiple episodes of induced secretion of human growth hormone from recombinant AtT-20 cells. Cytotechnology 1990 Sep; 4(2) 111-9.pmid:1367038. PubMed HubMed [4]
  156. Vallino JJ and Stephanopoulos GN. Intelligent sensors in biotechnology. Applications for the monitoring of fermentations and cellular metabolism. Ann N Y Acad Sci 1987; 506 415-30.pmid:3324860. PubMed HubMed [3]
  157. Fredrickson AG and Stephanopoulos G. Microbial competition. Science 1981 Aug 28; 213(4511) 972-9. pmid:7268409. PubMed HubMed [2]
  158. Stephanopoulos G, Schuelke LM, and Stephanopoulos G. A decomposition method for the stability analysis of large microbial systems. Theor Popul Biol 1979 Oct; 16(2) 126-43. pmid:538730.PubMed HubMed [1]

All Medline abstracts: PubMed HubMed

Publications in other databases

(A good place to check for other publications is the Web of Science)

  1. Hal Alper, and Gregory Stephanopoulos, (2004): Metabolic engineering challenges in the post-genomic era. Chemical Engineering Science, Vol. 59(22-23), Nov-Dec 2004; pp. 5009-5017.
  2. Schmitt, W., K. Jensen, and G. Stephanopoulos, (2002): Systems Bioengineering Challenges in Post-genomic Biological Research. Computers and Chemical Engineering.
  3. Geo. Stephanopoulos, D. Hwang, J. Misra, W.A. Schmitt, and Gr. Stephanopoulos, (2001): Functional Genomics and Systems Engineering. Proceedings of 6th IFAC Symposium on DYCOPS, Korea, June 4-6, 2001.
  4. Stephanopolous, Gr., and W. A. Schmitt, (2001): Systems Biology: an Emerging Theme in Biological Research. European Symposium on Computer Aided Process Engineering – 11, Int’l Conf., Copenhagen, May 27-30, 2001.
  5. M. Reinecke and G. Stephanopoulos, (2000): Flow Injection Analysis for Simultaneous Quantification of Prolactin Concentration and Glycosylation Macroheterogeneity in Cell Culture Samples. Cytotechnology, Vol. 34(3), November 2000; pp. 237-242.
  6. Maria I. Klapa and Gregory Stephanopoulos, “Metabolic flux analysis,” Chapter 3 in “Bioreaction Engineering, Modeling and Control,” K. Schugerl and K.H. Bellgardt (eds.), pp: 106-122, Springer, Berlin-Heidelberg-New York, (2000).
  7. Maria I. Klapa and G. Stephanopoulos, “Metabolic Engineering: A framework for the integration of genomic and physiological data,” in “NMR in Biotechnology: Theory and Applications,” pp. 453-477, Barbotin/Portais (eds.), Horizon Scientific Press, UK (2000).
  8. G. Taroncher-Oldenburg, R. T. Gill and G. Stephanopoulos, G. “Green biosynthesis of polyhydroxyalkanoates: Engineering of cyanobacteria for biopolymer production,” in: Proceedings 4th annual green chemistry and engineering conference, ACS, Washington, D.C., pp. 61-4 (2000).
  9. E. M. T. El-mansi and G. Stephanopoulos, “Flux control analysis: Basic principles and industrial applications,” chapter in Fermentation Microbiology and Biotechnology, pp. 179-196, (1999).
  10. G. Stephanopoulos, “Emerging directions in computer applications to biotechnology: Upgrading the information content of biological data,” Annual Reviews in Control, 23: 61-69, (1999).
  11. S. Bicciato, R. Kamimura, H. Shimizu, and G. Stephanopoulos, “Quantification of Data Clusters for Bioprocess Performance Classification via Artificial Intelligence,” Proceedings, IFAC Conf. Comp. Appl. to Biotech., Osaka, May 31-June 4, (1998).
  12. G. Stephanopoulos, “Emerging directions to computer applications to biotechnology: Upgrading the information content of biological data,” Proceedings, IFAC Conf. Comp. Appl. to Biotech., Osaka, May 31-June 4, (1998).
  13. S. M. Park, C. Shaw-Reid, A. J. Sinskey and G. Stephanopoulos, “Elucidation of Anaplerotic Pathways in Corynebacterium glutamicum via C13-NMR Spectroscopy and GC-MS”, Applied Microbiol. & Biotechn., 47: 430 – 440 (1997).
  14. J. Chung, C. Zabel, A. J. Sinskey and G. Stephanopoulos, “Extension of Sp2/0 Hybridoma Cell Viability Through IL-6 Supplementation”, Biotechnol. & Bioeng., 55: 439 – 446 (1997).
  15. T. W. Simpson and G. Stephanopoulos, “Flux Amplification in Complex Metabolic Networks”, Chem. Eng. Science, 52: 2607 – 2627 (1997).
  16. S. M. Park, A. J. Sinskey and G. Stephanopoulos, “Metabolic and Physiological Studies of Corynebacterium glutamicum mutants”, Biotechnol. & Bioeng., 55: 864-879 (1997).
  17. G. Stephanopoulos, G. Locher, M. J. Duff, R. Kamimura and Geo. Stephanopoulos, “Fermentation Database Mining by Pattern Recognition,” Biotechnol. & Bioeng., 53: 443-452 (1997).
  18. G. E. Grampp, H. F. Lodish and G. Stephanopoulos, “Processing and Secretion of Insulin Related Peptides in an Insulinoma Cell Line”, Biotechnol. & Bioeng., 53: 283-289 (1997).
  19. G. E. Grampp, H. F. Lodish and G. Stephanopoulos, “Analysis of Secretory Dynamics and Development of Media for the Controlled Secretion of Insulin-Related Peptides from *TC-3 Insulinoma Cells”, Biotechnol. & Bioeng., 53: 274-282 (1997).
  20. G. Stephanopoulos, “Kinetic Analysis of Complex Metabolic Networks”, Proceedings 14th Symposium on Energy Eng’g Sciences, Argonne Nat’l Lab, May 15, 16 (1996).
  21. G. Locher, B. Bakshi, Geo. Stephanopoulos, G. Stephanopoulos and K. Schügerl, “Ein Ansatz zur Automatischen Umwandlung von Rohdatten in Regeln Teil 2: Eine Fallstudie”, Automatisierungstechnik, 44: 138-145 (1996).
  22. G. Locher, B. Bakshi, Geo. Stephanopoulos, G. Stephanopoulos and K. Schügerl, “Ein Ansatz zur Automatischen Umwandlung von Rohdatten in Regeln”, Automatisierungstechnik, 44: 61-70 (1996).
  23. G. Stephanopoulos, G. Locher and M. Duff, “Pattern Recognition Methods for Fermentation Database Mining”, IFAC Proceedings, CAB6, Garmish, Germany (1996).
  24. M. Shelikoff, A.J. Sinskey and G. Stephanopoulos, “A Modeling Framework for the Study of Protein Glycosylation,” Biotechnol. & Bioeng., 50: 73-90 (1996).
  25. J. Chung and G. Stephanopoulos, “On Physiological Multiplicity and Population Heterogeneity of Biological Systems,” Chemical Eng. Science, 51: 1509-1521 (1996).
  26. G. Stephanopoulos, M. Applegate, R. Singhvi, S. Park and M.F. Stephanopoulos, “Cell Culturing Apparatus and Method Employing a Macroporous Support,” U.S. Patent No. 5,510,262 (1996).
  27. J.D. Chung and G. Stephanopoulos, “Studies of Transcriptional State Heterogeneity in Sporulating Cultures of Bacillus subtilis,” Biotechnol. & Bioeng. 47: 234-242 (1995).
  28. C. Zupke and G. Stephanopoulos, “Intracellular Flux Analysis in Hybridomas Using Mass Balances and in vitro C13 NMR,” Biotechnology & Bioengineering, 45: 292-303 (1995).
  29. R. Singhvi, G. Stephanopoulos and D.I.C. Wang, “Effects of Substratum Morphology on Cell Physiology,” Biotechnol. & Bioengin., 43, pp. 764-771 (1994).
  30. M. Gubler, S.M. Park, A.J. Sinskey and G. Stephanopoulos, “Effects of Phosphoenol Pyruvate Carboxylase Deficiency on Metabolism and Lysine Production in Corynebacterium glutamicum,” Appl. Microb. and Biotech., 40, pp. 857-868, (1994).
  31. B. Bakshi, G. Locher, G. Stephanopoulos, and Geo. Stephanopoulos, “Analysis of Data for Evaluation, Diagnosis and Control of Batch Operations,” J. of Process Control, 4, pp. 175-194 (1994).
  32. C. Zupke and G. Stephanopoulos, “Modeling of Isotope Distribution and Intracellular Fluxes in Metabolic Networks Using Atom Mapping Matrices,” Biotechnology Progress, 10, pp. 489-498 (1994).
  33. G. Locher, B. Bakshi, George Stephanopoulos, Gregory Stephanopoulos and K. Schgerl, “Database Mining (in German),” Chemical Ing. Tech., 66, Number 4, pp. 541-543 (1994).
  34. J.J. Vallino and G. Stephanopoulos, “Carbon Flux Distributions at the Pyruvate Branch Point in C. glutamicum during Lysine Overproduction,” Biotechnology Progress 10, pp. 327-334 (1994).
  35. J.J. Vallino and G. Stephanopoulos, “Carbon Flux Distributions at the Glucose-6 phosphate Branch Point in Corynebacterium glutamicum during Lysine Overproduction,” Biotechnology Progress 10, pp. 320-326 (1994).
  36. R. Singhvi, A. Kumar, D. Ingber, G. Whitesides, D.I.C. Wang and G. Stephanopoulos, “Method of Formation of Microstructured Patterns on Plates for Adhesion of Cells and Other Biological Materials, Devices and Uses There for,” U.S. Patent (filed) (1993).
  37. G. Stephanopoulos (ed.), “Bioprocessing,” Vol. 3 of Biotechnology, H.J. Rehm, G. Reed, A. Puhler, P. Stadler (series eds.), VCH, Weinheim (1993).
  38. G. Stephanopoulos and A.J. Sinskey, “Metabolic Engineering: Issues and Methodologies,” Trends in Biotechnology, Vol. 11, pp. 392-396 (1993).
  39. S. Park and G. Stephanopoulos, “Packed Bed Bioreactor with Porous Ceramic Beads for Animal Cell Culture,” Biotechnology & Bioengineering, 41, pp. 25-34, (1993).
  40. G. Stephanopoulos, K. Konstantinov, U. Saner and T. Yoshida, “Fermentation Data Analysis for Diagnosis and Control,” Chapter 15, pp. 355-400, in Bioprocessing, Vol. 3, G. Stephanopoulos (ed.), VCH Weinheim (1993).
  41. M.N. Karim and G. Stephanopoulos (eds.), “Modelling and Control of Biotechnical Processes,” IFAC Symposia Series No. 10, Proceedings of the 5th Int. Conf. of Computer App. in Ferm. Tech., Keystone, CO, 29 March – 2 April 1992, Pergamon Press (1992).
  42. S.M. Park and G. Stephanopoulos, “Applications of Metabolic Engineering to Metabolite Overproduction,” Proc. of 1st Spanish-Portuguese Congress on Biotechnology, Sept. 14-18, Santiago de Compostella, Spain (1992).
  43. S.M. Park and G. Stephanopoulos, “Regulation and Control of Metabolic Pathways,” Proceedings from Int’l Symposium on Information Sciences, July 11-15, Kyushu, Japan (1992).
  44. U. Saner and G. Stephanopoulos, “Application of Pattern Recognition Techniques to Fermentation Data Analysis,” pp. 123-128 in Modeling and Control of Biotechnical Processes 1992, M.N. Karim and G. Stephanopoulos (eds.), IFAC Symposia Series No. 10, Pergamon Press, Oxford, (1992).
  45. G. Stephanopoulos, “Fermentation Diagnosis and Control: Balancing Old Tools with New Concepts,” 9th Int’l Biotechnology Symposium, ACS Series, Crystal City, VA, August (1992).
  46. T. Chattaway, A.L. Demain and G. Stephanopoulos, “Use of Various Measurements for Biomass Estimation,” Biotechnology Progress, 8, pp. 81-84, (1992).
  47. R.D. Kiss and G. Stephanopoulos, “Culture Instability of Auxotrophic Aminoacid Producers,” Biotechnology & Bioengineering, 40, pp. 75-85, (1992).
  48. M.A. Applegate and G. Stephanopoulos, “Development of a Single-Pass Ceramic Matrix Bioreactor for Large-Scale Mammalian Cell Culture,” Biotechnology & Bioengineering, 40, pp. 1056-1068, (1992).
  49. R.D. Kiss and Gregory Stephanopoulos, “Metabolic Characterization of a L-Lysine Producing Strain by Continuous Culture,” Biotechnology & Bioengineering, 39, pp. 565-574, (1992).
  50. M. Mavrovouniotis, George Stephanopoulos and Gregory Stephanopoulos, “Synthesis of Biochemical Production Routes,” Computers in Chemical Engin’g., 16, pp. 605-619 (1992).
  51. M.J. Kennedy, M.S. Thakur, D.I.C. Wang and G. Stephanopoulos, “Estimating Cell Concentration in the Presence of Suspended Solids: A Light Scatter Technique,” Biotechnology & Bioengineering, 40, pp. 875-888, (1992).
  52. G. Stephanopoulos and R.D. Kiss, “Bioreactor Monitoring and Control,” Encyclopedia of Microbiology, J. Lederberg (ed.), Academic Press, Inc., vol. 1, pp. 351-362 (1992).
  53. R. Singhvi, G. Stephanopoulos and D.I.C. Wang, “Effect of Substratum Morphology on Animal Cell Adhesion and Behavior,” Proceedings MRS Conference, Boston, Nov. (1991).
  54. Y. Shoham, G. Stephanopoulos and A.L. Demain, “Effects of the á-Lactamase Gene and Orientation of the Kanamycin Resistance Gene in Plasmids pCED3 on the Growth of Bacillis subtilis,” J. Ferm. Bioeng., 72, pp. 244-248, (1991).
  55. R.D. Kiss and G. Stephanopoulos, “Metabolic Activity Control of L-Lysine Fermentation by Restrained Growth Fed-Batch Strategies,” Biotechnology Progress, 7, pp. 501-509, (1991).
  56. A. Sambanis, G. Stephanopoulos and H.F. Lodish, “A Model of Secretory Protein Trafficking in Recombinant AtT-20 Cells,” Biotechnology & Bioengineering, 38, pp. 280-295 (1991).
  57. Gregory Stephanopoulos and Seujeung Park, “Bioreactor State Estimation,” Chapter 2.7 of Vol. 4, pp. 225-249 “Measuring, Modeling, and Control,” of “Biotechnology-A Multi-volume Comprehensive Treatise,” H.J. Rehm and G. Reed (eds.), Verlagsgesellschaft (1991).
  58. M. Mavrovouniotis, George Stephanopoulos and Gregory Stephanopoulos, “Estimation of Upper Bounds for the Rates of Enzymatic Reactions,” Chem. Eng. Commun., 93, pp. 211-236 (1990).
  59. J.J. Vallino and Gregory Stephanopoulos, “Intracellular Flux Analysis As Means of Identifying Limiting Nodes in Amino Acid Fermentations,” Proc. 5th European Congress on Biotechnology, Copenhagen, July 8-13 (1990).
  60. M. Mavrovouniotis, George Stephanopoulos and Gregory Stephanopoulos, “Computer-Aided Synthesis of Biochemical Pathways,” Biotechnol. & Bioengineering, 36, pp. 1119-1132 (1990).
  61. G. Stephanopoulos and R. Singhvi, “Accomplishments in Biochemical Engineering,” chapter in Biotechnology: Science, Education & Commercialization, I.K. Vasil (ed.), Elsevier (1990).
  62. M. Kennedy, D.I.C. Wang and G. Stephanopoulos, “Measurements of Solid Particle Concentration in Presence of a Second Particle Type,” U.S. Patent No. 4,969,741 (1990).
  63. B.J.M. Hannoun and G. Stephanopoulos, “Growth and Fermentation Model for Alginate-Entrapped Saccharomyces cerevisiae,” Biotechnology Progress, 6, pp. 349-356 (1990).
  64. B.J.M. Hannoun and G. Stephanopoulos, “Intrinsic Growth and Fermentation Rates of Alginate-Entrapped Saccharomyces cerevisiae,” Biotechnology Progress, 6, pp. 341-348 (1990).
  65. R.D. Kiss, M.T. Follettie, and G. Stephanopoulos, “Quantitative Assay for Low Levels of L. Threonine in Amino Acid Fermentation Broths,” Biotechnol. and Bioengin. 35, pp. 1169-1173 (1990).
  66. A. Sambanis, G. Stephanopoulos, H.F. Lodish, and A.J. Sinskey, “Use of Regulated Secretion in Protein Production from Animal Cells: A First Evaluation with the AtT-20 Model Cell Line,” Biotechnol and Bioengin. 35, pp. 771-780 (1990).
  67. R. Grosz and G. Stephanopoulos, “Physiological, Biochemical and Mathematical Studies of Microaerobic Continuous Ethanol Fermentation by Saccharomyces cerevisiae. Part III,” Biotechnol. and Bioengin. 36, pp. 1030-1040 (1990).
  68. R. Grosz and G. Stephanopoulos, “Physiological, Biochemical and Mathematical Studies of Microaerobic Continuous Ethanol Fermentation by Saccharomyces cerevisiae. Part II,” Biotechnol. and Bioengin. 36, pp. 1020-1029 (1990).
  69. Ron Grosz and G. Stephanopoulos, “Physiological, Biochemical and Mathematical Studies of Microaerobic Continuous Ethanol Fermentation by Saccharomyces cerevisiae. Part I,” Biotechnol. and Bioengin. 36, pp. 1006-1019 (1990).
  70. J.J. Vallino and G. Stephanopoulos, “Flux Determination in Cellular Bioreaction Networks. Application to Lysine Fermentations,” Frontiers in Bioprocessing, S. Sikdar, M. Bier, P. Todd (eds.), pp. 205-219, CRC Press, Inc., Boca Raton, FL (1990).
  71. G. Stephanopoulos, J. Kornfield and G.E. Voecks, “Monolith Reactor Containing a Plurality of Flow Passages and Method for Carrying Out Biological Reactions,” U. S. Patent No. 4,948,728 (1990).
  72. T. Chattaway and G. Stephanopoulos, “An Adaptive State Estimator for Detecting Contaminants in Bioreactors,” Biotechnol. and Bioengin., 34, pp. 647-659 (1989).
  73. K.Y. San and G. Stephanopoulos, “Optimization of Fed-Batch Penicillin Fermentation. A Case of Singular Optimal Control with State Constraints,” Biotechnol. and Bioeng. 34, pp. 72-78 (1989)
  74. T. Chattaway and G. Stephanopoulos, “Adaptive Estimation of Bioreactors: Monitoring Plasmid Instability,” Chem. Eng. Science, 44, pp. 41-48 (1989).
  75. M. R. Hoffmann, R. G. Arnold, and Gregory Stephanopoulos, “Microbial Reduction of Iron Ore,” U. S. Patent No. 4,880,740 (1989).
  76. M. Mavrovouniotis, George Stephanopoulos and Gregory Stephanopoulos, “Formal Modeling of Approximate Relations in Biochemical Systems,” Biotechn. and Bioengin., 34, pp. 196-206 (1989).
  77. G. Stephanopoulos and K. Tsiveriotis, “The Effect of Intraparticle Convection on Nutrient Transport in Porous Biological Pellets,” Chem. Eng. Science, 44, pp. 2031-2039, (1989).
  78. T. Chattaway and G. Stephanopoulos, “Adaptive Monitoring of Bioreactor Contamination,” Proc. IV Intern. Conf. Comp. Applic. to Fermentation Technology, Cambridge, England (1988).
  79. Gregory Stephanopoulos and K. Tsiveriotis, “Toward a Systematic Method for the Generalization of Fermentation Data,” Proc. IV Intern. Conf. Comp. Applic. to Fermentation Technology, Cambridge, England (1988).
  80. M. Mavrovouniotis, P. Bayol, T.K. Lam, George Stephanopoulos and Gregory Stephanopoulos, “A Group Contribution Method for the Estimation of Equilibrium Constants for Biochemical Reactions,” Biotechnol. Techniques, 2, pp. 23-28 (1988).
  81. K.Y. San, G. Stephanopoulos, N.S. Wang, and E.T. Papoutsakis, “Measurement, Data Analysis, and Control of Anaerobic Digesters,” Chapter 12 in Handbook on Anaerobic Fermentations, L.E. Erickson and D.Y.C. Fung (eds.) pp. 441-462, Marcel Dekker, Inc., New York (1988).
  82. G. Stephanopoulos, “Modeling Mixed Culture Interactions in Anaerobic Digestion. Application to Digester Start-Up and Control,” Chapter 19 in Handbook on Anaerobic Fermentations, L.E. Erickson and D.Y.C. Fung (eds.) pp. 597-639, Marcel Dekker, Inc., New York (1988).
  83. G. Stephanopoulos and G.R. Lapidus, “Chemostat Dynamics of Plasmid-Bearing, Plasmid-Free Mixed Recombinant Cultures,” Chem. Eng. Sci. 43, pp. 49-57 (1988).
  84. T. Chattaway and G. Stephanopoulos, “A New Technique for Estimation of Bioreactors: Adaptive State Observers,” Proc. of Intern. Workshop on Control of Biotechnical Processes, Univ. of Newcastle, (1987).
  85. G. Stephanopoulos, “Problems and Opportunities in Bioreactor Control,” Proc. 4th Mediterranean Congress of Chem. Eng., Vol. I, pp. 71-84 Barcelona, Nov. 11-13 (1987).
  86. M.L. Mavrovouniotis, George Stephanopoulos and Gregory Stephanopoulos, “A User Interface for the Design of Biochemical Pathways,” Proc. of AAAI Conf., (1987)
  87. L.E. Erickson and G. Stephanopoulos, “Biological Reactors,” chapter 12 in Chemical Reaction and Reactor Engineering, J.J. Carberry and A. Varma (eds.), pp. 779-838, Marcel Dekker, Inc., New York (1987).
  88. George Stephanopoulos and Gregory Stephanopoulos, “Artificial Intelligence in the Development and Design of Biochemical Processes,” Trends in Biotechnology, 4, pp. 241-249 (1986).
  89. B.H. Davison and G. Stephanopoulos, “Coexistence of S. cerevisiae and E. coli in a Chemostat under Substrate Competition and Product Inhibition,” Biotech. and Bioeng., 28, pp. 1742-1752 (1986).
  90. B.J.M. Hannoun and G. Stephanopoulos, “Diffusion Coefficients of Glucose and Ethanol in Cell-Free and Cell-Occupied Calcium Alginate Membranes,” Biotech. and Bioeng., 28, pp. 829-835 (1986).
  91. G. Stephanopoulos, “A New Approach to Bioprocess Modelling,” Proc. 1st IFAC Symposium on Mod. and Control of Biotechnological Processes, (1986).
  92. G. Stephanopoulos, “Application of Macroscopic Balances and Bioenergetics of Growth to the On-Line Identification of Biological Reactors,” Annals N.Y. Acad. Sci., Vol. 469, Bioch. Eng. IV, pp. 332-349 (1986).
  93. B.H. Davison and G. Stephanopoulos, “Effect of pH Oscillations on a Competing Mixed Culture,” Biotech. and Bioeng., 28, pp. 1127-1137 (1986).
  94. J. Kornfield and G. Stephanopoulos, “Oxygen Transfer in Membrane-Ceramic Composite Materials for Immobilized-Cell Monolithic Reactors,” Biotechnology Progress, 2, pp. 98-104 (1986).
  95. A. Dalla Torre and G. Stephanopoulos, “A Simulation Study of Anaerobic Digestor Control,” Biotech. and Bioeng., 28, pp. 1138-1153 (1986)
  96. A. Dalla Torre and G. Stephanopoulos, “A Mixed Culture Model of Anaerobic Digestion. Application to the Evaluation of Start-Up Procedures,” Biotech. and Bioeng., 28, pp. 1106-1118 (1986)
  97. K.Y. San and G. Stephanopoulos, “The Effect of Growth Rate Delays on the Optimal Profile of Fed-Batch Reactors,” Biotech. and Bioeng., 28, pp. 356-361 (1986).
  98. B.H. Davison, K.Y. San, and G. Stephanopoulos, “Stable Competitive Coexistence in a Continuous Fermentor with Size-Selective Properties, “Biotechnology Progress, 1, pp. 260-268 (1985).
  99. G. Stephanopoulos, K.Y. San, and B.H. Davison, “A Novel Bioreactor-Cell Precipitator Combination for High-Cell Density, High-Flow Continuous Fermentations,” Biotechnology Progress, 1, pp. 250-259 (1985).
  100. Dorian Liepmann and G. Stephanopoulos, “A Closed Ecosystem Model: Development and Global Sensitivity Analysis,” Ecological Modelling 30, pp. 13-47 (1985).
  101. Nam Sun Wang and G. Stephanopoulos, “A New Approach to Bioprocess Modelling and Identification,” Biotech. and Bioeng., Symp. No. 14, pp. 635-656 (1984).
  102. G. Stephanopoulos and K.Y. San, “Application of Enhanced Sedimentation in an Integrated Fermentor Design for Simultaneous Fermentation and Cell Recycle,” Proceedings 3rd European Congress on Biotechnology, Sept. 10, 1984, Vol. II, 253 (1984).
  103. K.Y. San and G. Stephanopoulos, “A Note on the Optimality Criteria for Maximum Biomass Production in a Fed-Batch Reactor,” Biotech. and Bioeng., 26, pp. 1261-1264 (1984).
  104. N.S. Wang and G. Stephanopoulos, “Computer Applications to Fermentation Processes,” CRC Critical Reviews in Biotech. 2, 1-103 (1984).
  105. K.Y. San and G. Stephanopoulos, “Studies on On-Line Bioreactor Identification. IV. Utilization of pH Measurements for Product Estimation,” Biotech. and Bioeng., 26, 1209-1218 (1984).
  106. R. Grosz, G. Stephanopoulos, and K.Y. San, “Studies on On-Line Bioreactor Identification. III. Sensitivity Problems with Respiratory Quotient and Heat Evolution Measurements,” Biotech. and Bioeng., 26, 1198-1208 (1984).
  107. K.Y. San and G. Stephanopoulos, “Studies on On-Line Bioreactor Identification. II. Numerical and Experimental Results,” Biotech. and Bioeng., 26, pp. 1189-1197 (1984).
  108. G. Stephanopoulos and K.Y. San, “Studies on On-Line Bioreactor Identification. I. Theory”, Biotech. and Bioeng., 26, pp. 1176-1188 (1984).
  109. N.S. Wang and G. Stephanopoulos, “Application of Macroscopic Balances to the Identification of Gross Measurement Errors,” Biotech. and Bioeng., 25, pp. 2177-2208 (1983).
  110. R. Grosz and G. Stephanopoulos, “Statistical Mechanical Estimation of the Free Energy of Formation of E. coli Biomass for Use with Macroscopic Bioreactor Balances,” Biotech. and Bioeng., 25, pp. 2149-2163 (1983).
  111. G. Stephanopoulos and K.Y. San, “On-Line Estimation of Time Varying Parameters. Application to Biochemical Reactors,” Modeling and Control of Biotechnical Process, Proc. of 1st IFAC Workshop, A. Halme (ed.), pp. 195-200 (1983).
  112. K.Y. San and G. Stephanopoulos, “Optimal Control Policy for Substrate-Inhibited Kinetics with Enzyme Deactivation in an Isothermal CSTR,” AIChE J., 29, pp. 417-424 (1983).
  113. H.W. Blanch, T. Papoutsakis, and G. Stephanopoulos, (eds.), “Foundations of Biochemical Engineering. Kinetics and Thermodynamics in Biological Systems, “papers presented at the 1982 ACS/IEC Winter Symposium on Biochemical Engineering, Jan. 17-20, 1983, Boulder, Colorado. ACS Symposium Series, 207 (1983)
  114. G. Stephanopoulos and K.Y. San, “On-Line Estimation of the State of Biochemical Reactors,” ACS Symposium Series, 196, pp. 155-164 (1982).
  115. G. Stephanopoulos, “The Dynamics of Commensalism,” Biotech. and Bioeng., 23, pp. 2243-2255 (1981).
  116. G. Stephanopoulos and K.Y. San, “State Estimation for Computer Control of Biochemical Reactors,” Proc. of VIth Ferm. Symp., July 20-25, 1980, London, Canada, Volume I, pp. 399-406, M. Moo-Young, C.W. Robinson, C. Vezino (eds.) (1981).
  117. G. Stephanopoulos and A.G. Fredrickson,” Extinction Probabilities in Microbial Predation: A Birth and Death Approach,” Bulletin of Math. Biology, 43, pp. 165-181 (1981).
  118. Gregory Stephanopoulos, “Zero Concentration Surfaces in a Cylindrical Catalyst Pellet,” Chem Eng. Science, 35, pp. 2345-2349 (1980).
  119. Gregory Stephanopoulos, “Dynamics of Mixed Cultures of Microorganisms: Topological Considerations,” AIChE J., 25, pp. 802-816 (1980).
  120. P. Michalopoulos, Gregory Stephanopoulos, and V.B. Pisharody, “Modeling of Traffic Flow at Signalized Links,” Transp. Science, 14, pp. 9-41 (1980).
  121. P. Michalopoulos, Gregory Stephanopoulos, and George Stephanopoulos, “An Application of Shock Wave Theory to Traffic Signal Control,” Trans. Research Volume 15B, pp. 35-51 (1980).
  122. Gregory Stephanopoulos and A.W. Westerberg, “Modular Design of Heat Exchanger Networks,” Chem. Eng. Communications, 4, pp. 119-126 (1980).
  123. George Stephanopoulos and Gregory Stephanopoulos, “An Alternative Approach to the Optimization of Constrained Design Problems,” Chem. Eng. Communications, 4, pp. 173-181 (1980).
  124. P. Michalopoulos, George Stephanopoulos, V.B. Pisharody, and Gregory Stephanopoulos, “Formation and Dissipation of Traffic Queues: Some Macro-scopic Considerations,” Trans. Res. Board, pp. 81-84 (1979).
  125. Gregory Stephanopoulos, George Stephanopoulos, and P. Michalopoulos, “Real Time Control of Critical Intersections Based on Queue Dynamics”, Proc. 17th IEEE Conf. on Decision and Control, San Diego, CA, pp. 1018-1024 (1979).
  126. Gregory Stephanopoulos and A.G. Fredrickson, “The Effect of Spatial Inhomogeneities on the Coexistence of Competing Microbial Populations,” Biotech. and Bioeng., 21, pp. 1491-1498 (1979).
  127. Gregory Stephanopoulos, P. Michalopoulos, and George Stephanopoulos, “Modelling and Analysis of Traffic Queue Dynamics at Signalized Inter-sections,” Transp. Res., 13A, pp. 295-307 (1979).
  128. G. Stephanopoulos and A.G. Fredrickson, “Coexistence of Photosynthetic Microorganisms with Growth Rates Depending on the Spectral Quality of Light,” Bull. of Math, Biology, 41, pp. 525-542 (1979).
  129. G. Stephanopoulos, A.G. Fredrickson, and R. Aris, “The Growth of Competing Microbial Populations in a CSTR with Periodically Varying Inputs,” AIChE J., 25, pp. 863-872 (1979).
  130. Gregory Stephanopoulos, R. Aris, and A.G. Fredrickson, “A Stochastic Analysis of the Growth of Competing Microbial Populations in a Continuous Biochemical Reactor,” Mathematical Biosciences, 45, pp. 99-135 (1979).
  131. George Stephanopoulos and Gregory Stephanopoulos, “The Synthesis of Heat Recovery Networks for Chemical Processes,” Proceedings Inter. Conf. Energy Use Management, Tucson, Arizona, pp. 123-134 (1977)