Because cells exist far from chemical equilibrium, a kinetic description of metabolism is required to predict the effects of genetic interventions. Such a kinetic description must start with the fluxes through the major pathways of central carbon metabolism. Although these intracellular metabolic fluxes cannot be measured directly, they can be estimated by feeding carbon sources [...]
Tumor cells commonly exhibit aerobic glycolysis, or the “Warburg effect,” a metabolic transformation that allows cells to undergo enhanced proliferation without significant respiration, despite the presence of oxygen. While the origins of this effect are still not completely understood, it is directly connected with tumorigenesis through mutation or differential expression of several metabolic enzymes. As such, [...]
Hometown: Ghent, Belgium. Undergraduate Institution: Ghent University Graduate Institution: Delft University of Technology, Ghent University, Massachusetts Institute of Technology Project: Creation of molecular biological tools that enable fine-tuning of gene expression Contact Information: mademey@mit.edu Creation of molecular biological tools that enable fine-tuning of gene expression The dependence on limiting [...]
Books Gregory N. Stephanopoulos, Aristos A. Aristidou, Jens Nielsen. Metabolic engineering. San Diego: Academic Press, 1998. isbn:0126662606. [1B] edited by Isidore Rigoutsos and Gregory Stephanopoulos. Systems biology. New York: Oxford University Press, 2007. isbn:0195300815. [2B] edited by Isidore Rigoutsos and Gregory Stephanopoulos. Systems biology. New York: Oxford University Press, 2007. isbn:0195300807. [3B] Publications accessible in PubMed Tyo KE, Nevoigt E, Stephanopoulos G. Directed [...]
